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Tags: an alzheimer's drug that doesn't treat alzheimer's?fdagreeneducationlearnalzheimer'shankbiomarkersscishowamyloid-betaamyloid hypothesisamyloid precursor proteinscienceclinical trialsaducanumabamyloid plaque

Description: Head to linode.com/scishow to get a $100 60-day credit on a new Linode account. Linode offers simple, affordable, and accessible Linux cloud solutions and services. In 2021, the FDA approved a treatment that claims to stop Alzheimer's at the source, removing the plaques in the brain long thought to cause the symptoms of the disease. But, as is often the case, things are more complicated than they first appear. Hosted by: Michael Aranda SciShow is on TikTok! Check us out at tiktok.com/@scishow ---------- Support SciShow by becoming a patron on Patreon: patreon.com/scishow ---------- Huge thanks go to the following Patreon supporters for helping us keep SciShow free for everyone forever: Tomás Lagos González, Sam Lutfi. Bryan Cloer, Christoph Schwanke, Kevin Bealer, Jacob, Jason A Saslow, Nazara, Tom Mosner, Ash, Eric Jensen, Jeffrey Mckishen, Matt Curls, Alex Hackman, Christopher R Boucher, Piya Shedden, Jeremy Mysliwiec, charles george, Chris Peters, Adam Brainard, Dr. Melvin Sanicas, Harrison Mills, Silas Emrys, Alisa Sherbow ---------- Looking for SciShow elsewhere on the internet? SciShow Tangents Podcast: scishow-tangents.simplecast.com Facebook: facebook.com/scishow Twitter: twitter.com/scishow Instagram: instagram.com/thescishow #SciShow ---------- Sources: health.harvard.edu/blog/a-new-alzheimers-drug-has-been-approved-but-should-you-take-it-202106082483 fda.gov/news-events/press-announcements/fda-grants-accelerated-approval-alzheimers-drug pubmed.ncbi.nlm.nih.gov/12130773 statnews.com/2016/11/14/alzheimers-brain-amyloid-plaque science.org/doi/10.1126/science.1566067 ncbi.nlm.nih.gov/pmc/articles/PMC3174086 science.org/doi/pdf/10.1126/science.2933807 bmj.com/content/372/bmj.n156 nature.com/articles/d41586-021-01546-2 neurologylive.com/view/aducanumab-phase-4-real-world-observational-study-announced ncbi.nlm.nih.gov/pmc/articles/PMC5278466 pubmed.ncbi.nlm.nih.gov/9189035 alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.12213 orthopeden.org/downloads/242/Standardizing%20Patient%20Outcomes%20Measurement.pdf jamanetwork.com/journals/jamaneurology/fullarticle/1107509 biopharma-reporter.com/Article/2021/12/20/Aducanumab-rejected-in-the-EU-Biogen-will-ask-EMA-to-re-examine-application sciencedirect.com/topics/neuroscience/tau-protein alz.org/media/Documents/alzheimers-dementia-tau-ts.pdf pubmed.ncbi.nlm.nih.gov/9386780 ncbi.nlm.nih.gov/pmc/articles/PMC3560290 youtu.be/E6PgRD-CsYo?t=795 youtu.be/E6PgRD-CsYo?t=1908 youtu.be/E6PgRD-CsYo?t=625 brightfocus.org/alzheimers/article/tau-protein-and-alzheimers-disease-whats-connection lexico.com/en/definition/glia ncbi.nlm.nih.gov/pmc/articles/PMC5394397 cell.com/molecular-therapy-family/nucleic-acids/fulltext/S2162-2531(21)00067-6?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2162253121000676%3Fshowall%3Dtrue alzheimersresearchuk.org/tackling-tau-scientists-find-local-spread-is-how-alzheimers-progresses ncbi.nlm.nih.gov/pmc/articles/PMC3713404 jbc.org/article/S0021-9258(20)47639-2/fulltext pubmed.ncbi.nlm.nih.gov/29053874 Images: commons.wikimedia.org/wiki/File:Amyloid_03big1.jpg commons.wikimedia.org/wiki/File:Beta-Amyloid_Plaques_and_Tau_in_the_Brain_(38686503251).png en.wikipedia.org/wiki/File:APP_processing.png commons.wikimedia.org/wiki/File:Astrocytes_surrounding_amyloid_plaques_III.tif commons.wikimedia.org/wiki/File:Alzheimers_Disease.jpg commons.wikimedia.org/wiki/File:Entorhinal_-_DK_ATLAS.png commons.wikimedia.org/wiki/File:Gray739-emphasizing-hippocampus.png commons.wikimedia.org/wiki/File:Neurofibrillary_tangles_in_the_Hippocampus_of_an_old_person_with_Alzheimer-related_pathology,_HE_1.JPG commons.wikimedia.org/wiki/File:Brain-derived_neurotrophic_factor_-_PDB_id_1BND.png frontiersin.org/articles/10.3389/fnins.2019.01274/full