Channel: FoundMyFitness

Category: Science & Technology

Tags: epigenetic clockshorvath aging clockgrimagephenoageaging clocksepigenetic aging clocksepigenetics

Description: Steve Horvath, PhD, ScD is a professor of human genetics and biostatistics at UCLA's Fielding School of Public Health. Dr. Horvath is the creator of the Horvath Epigenetic Aging Clock. His work incorporates elements of biostatistics, genetics, epidemiology, epigenomics, and other fields of study. He applies his understanding of this diverse range of disciplines to study a spectrum of chronic diseases, including cancer, cardiovascular disease, neurodegenerative disease, and other diseases of aging. Dr. Horvath's so-called "pan-tissue epigenetic aging clock" is an algorithm that accurately predicts a person's chronological age from marks on the DNA across multiple cells, tissues, and organs, and even mammalian species. Further refining this initial algorithm, Dr. Horvath built on this to develop second-generation clock algorithm that could predict time-to-death among people of the same chronological age, as well as lifespan and healthspan. One of these clocks, the GrimAge clock, is named deliberately after its connotation: predicting time until death ("Grim"). In this episode, Dr. Steven Horvath describes epigenetic clocks and their role in predicting – and possibly slowing – aging GET THE SHOW NOTES: foundmyfitness.com/episodes/steve-horvath (👆↑ You'll really want these. These notes have clips, in-depth timeline, quotes, a glossary, a transcript, and more.) Dr. Horvath's faculty bio page: ph.ucla.edu/faculty/horvath Dr. Horvath's Wikipedia page: en.wikipedia.org/wiki/Steve_Horvath Dr. Rhonda Patrick's 3-minute video crash course in epigenetics: foundmyfitness.com/episodes/epigenetic-clock The FoundMyFitness OVERVIEW ARTICLE on epigenetic clocks: foundmyfitness.com/topics/epigenetic-clocks (👆↑ This article has dozens of citations!) CHAPTERS 00:00:00 - Introductions 00:00:34 - Horvath Aging Clock 00:01:50 - Explaining the error rate 00:06:42 - Hereditary + lifestyle factors 00:15:03 - DNAm PhenoAge vs GrimAge 00:22:50 - Telomere science shortcomings 00:26:08 - Prolonging the epigenetic clock 00:50:56 - Epigenetics: Cause or consequence of aging? 00:56:53 - Vitamin D reverses epigenetic age 00:59:20 - Omega-3 slows down the GrimAge clock 01:04:27 - Ongoing research ⏳ #aging #longevity #epigenetics 🧬